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GATA factors were first identified as proteins that interact with conservedWGATAR (W = T orA; R = Gor A) motifs involved in erythroid-specific gene expressionin vertebrates.
GATA factors are characterised by the presence of conserved, type-IV zinc-finger motifs Animal factors typically contain two C-x2-Cx17-C-x2-C zinc-finger domains.The majority of known fungal GATA factors
contain a single C-x2-C-x17-C-x2-C finger with greatest similarity to the carboxyl (C) terminal finger of
animal GATA factors.Several examples of fungal GATA factors containing a variant C-x2-C-x18-C-x2-C DNA-binding domain are also known.
Examples of both C-x2-C-x17-Cx2-C (Type IVa) and C-x2-C-x18-C-x2-C (Type IVb) GATA factors are found within fungi; animals onlycontain the former configuration, and plants only the latter.Plant GATA factors typically contain a single zinc finger.The Arabidopsis type-IV zinc-finger proteins may represent the
previously defined family of nuclear GATA-binding proteins implicated in light-responsive transcription.
Teakle GR, Manfield IW, Graham JF, Gilmartin PM.
Arabidopsis thaliana GATA factors: organisation, expression and DNA-binding characteristics.
Plant Mol Biol. 2002 Sep;50(1):43-57.
PMID: 12139008
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